NIH Blueprint: The Human Connectome Project

HCP Lifespan Pilot Project

Phase 1b Lifespan Pilot Parameters

Study Design

Facility WU (3T Connectom) UMinn (3T Prisma) UMinn (7T)
Modalities Structural, rfMRI, tfMRI, dMRI Structural; rfMRI, dMRI rfMRI, dMRI**
Age group Number of participants
4-6 22 - -
8-9 22 20 20
14-15 22 20 20
25-35* 22 20 20
45-55 22 20 20
65-75 22 20 20


* Inclusion of the 25-35 age group is necessary to bridge between HCP results and the shorter protocol required across age ranges in a Lifespan study design
** 7T diffusion and rfMRI data will be analyzed using 3T Prisma structural scans from the same participants.

Note 1: 32 channel head coil used for Prisma.

Note 2: A custom-built pediatric head coil is used for children ages 4-6

Scanning Parameters

Facility WU (3T Connectom) UMinn (3T Prisma) UMinn (7T)
Structural 0.8mm isotropic 0.8mm isotropic N/A*
rfMRI 2mm isotropic, MB8, TR 720 ms; RL, LR phase encoding 2mm isotropic, MB8; TR 720 ms; AP, PA phase encoding 1.6mm isotropic, MB5 x iPAT2; TR 1000 ms; AP, PA phase encoding
tfMRI 2mm isotropic, MB8, TR 720 ms; RL, LR phase encoding 4 tasks Not done Not done
dMRI 1.5mm isotropic, MB3
b= 1500, 3000
75 directions in each shell acquired with both RL and LR phase encoding
1.5mm isotropic, MB4
b= 1500, 3000
92 directions in each shell acquired with both AP and PA phase encoding
1.25mm isotropic, MB2 x iPAT3
b= 1000, 2000
53 directions in each shell acquired with both AP and PA phase encoding


* Scan analysis uses Prisma structural scan from same participant

For the 3T Connectom Lifespan scan protocols (ages 14-55), click here: LS_Phase1b_14-55yo_2014.06.12.pdf.

For the 3T Prisma Lifespan scan protocols, click here: LSCMRR_3T_printout_2014.08.15.pdf.

For the 7T Lifespan scan protocols, click here: LSCMRR_7T_printout_2014.08.15.pdf

Scan type, duration, and order for WashU 3T Connectom scanner (Phase 1b)

Ages 4-6 Ages 8-9 and 65-75 14-15, 25-35, 45-55

Session A (35 min)

  • rfMRI-1 (2 x 3 min)
  • structural T1w structural
  • T2w rfMRI-2 (2 x 3 min)
  • tfMRI emotion task (modified)

Session A (52 min)

  • rfMRI-1 (2 x 5 min)
  • structural T1w structural
  • T2w rfMRI-2 (2 x 5 min)
  • tfMRI working memory
  • tfMRI emotion

Session A (62 min)

  • rfMRI-1 (2 x 5 min)
  • structural T1w
  • structural T2w
  • rfMRI-2 (2 x 5 min)
  • tfMRI working memory
  • tfMRI emotion
  • structural T1w_vNAV

Session B (44 min)

  • rfMRI-3 (2 x 3 min)
  • dMRI-1 (2 x 5 min)
  • dMRI-2 (2 x 5 min)
  • rfMRI-4 (2 x 3 min)
  • tfMRI social cognition

Session B (59 min)

  • rfMRI-3 (2 x 5 min)
  • dMRI-1 (2 x 5 min)
  • dMRI-2 (2 x 5 min)
  • rfMRI-4 (2 x 5 min)
  • tfMRI social cognition
  • tfMRI gambling

Session B (59 min)

  • rfMRI-3 (2 x 5 min)
  • dMRI-1 (2 x 5 min)
  • dMRI-2 (2 x 5 min)
  • rfMRI-4 (2 x 5 min)
  • tfMRI social cognition
  • tfMRI gambling

Session C* (if possible; 33 min)

  • rfMRI-5 (2 x 3 min)
  • structural T1w_vNav
  • structural T2w
  • tfMRI gambling (modified)

Session C* (if possible; 40 min)

  • rfMRI-5 (2 x 5 min)
  • structural T1w_vNav
  • structural T2w
  • rfMRI- 6 (2 x 5 min)
 


*Session C is an “if possible” session, as it would help to have the vNav comparisons for all age groups, but some participants may not tolerate having 3 scan sessions.

Scan type, duration, and order for UMinn 3T Prisma scanner (Phase 1b)

20 subjects per age group at ages 8-9, 14-15, 25-25, 45-55 and 65-75.  Children age 4-6 will not be scanned at UMinn, since the necessary custom pediatric coil is at WashU.

All Age Groups

1 Session (59 min)

  • rfMRI-1 (2 x 5 min)
  • structural T1w
  • structural T2w
  • dMRI-1 (2 x 5 min)
  • rfMRI-2 (2 x 5 min)
  • dMRI-2 (2 x 5 min)
Scan Type Duration
1 Localizer 00:14
2 AAHead_Scout_32ch-head-coil 00:14
3 Localizer_aligned 01:00
4 BIAS_BC 00:28
5 BIAS_32CH 00:28
6 SpinEchoFieldMap_PA 00:31
7 SpinEchoFieldMap_AP 00:31
8 rfMRI_REST_AP 05:12
9 rfMRI_REST_PA 05:12
10 T1w_MPR 06:38
11 T2w_SPC 05:57
12 DWI_dir98_AP 05:35
13 DWI_dir98_PA 05:35
14 SpinEchoFieldMap_PA 00:31
15 SpinEchoFieldMap_AP 00:31
16 rfMRI_REST_AP 05:12
17 rfMRI_REST_PA 05:12
18 DWI_dir99_AP 05:38
19 DWI_dir99_PA 05:38
Total: 1:00:17

 

Scan type, duration, and order for UMinn 7T scanner (Phase 1b)

20 subjects per age group at ages 8-9, 14-15, 25-25, 45-55 and 65-75.  Children age 4-6 will not be scanned at 7T.

All Age Groups

1 Session (58 min)

  • rfMRI-1 (2 x 5 min)
  • dMRI-1 (2 x 5 min)
  • rfMRI-2 (2 x 5 min)
  • dMRI-2 (2 x 5 min)
Scan Type Duration
1 Localizer 00:06
2 AAHScout_32ch 00:09
3 Localizer_aligned 00:23
4 AFI 03:01
5 SpinEchoFieldMap_PA 01:26
6 SpinEchoFieldMap_AP 01:26
7 rfMRI_REST_AP 06:20
8 rfMRI_REST_PA 06:20
9 DWI_dir98_AP 06:25
10 DWI_dir98_PA 06:25
11 SpinEchoFieldMap_PA 01:26
12 SpinEchoFieldMap_AP 01:26
13 rfMRI_REST_AP 06:20
14 rfMRI_REST_PA 06:20
15 DWI_dir57_AP 06:19
16 DWI_dir57_PA 06:19
17 FieldMap_Diffusion 01:02
Total: 1:01:13